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Resistance to ribociclib was generated from PDX244 (ER+, PDX244LR) after prolonged drug exposure (Fig. 1D)8 and from PDX153 (HER2+, PDX153LR), spontaneously after 7 serial passages in the absence of drug. Both of these ribociclib-resistant models maintained the histopathological features of their respective sensitive counterpart (Supplementary Table 1). In summary, we tested the sensitivity to ribociclib in 23 BC PDXs, including two models that acquired resistance to ribociclib from the sensitive counterparts. 2b1af7f3a8

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